Tear lactate improves the evaluation of proliferative diabetic retinopathy in type-2 diabetes patients.

ABSTRACT: Proliferative diabetic retinopathy (PDR) is the advanced stage of DR and characterized by retinal neovascularization (RNV). The diagnosis of PDR relies primarily on imaging features and blood glucose levels. Whether early biomarkers in other biofluid applied in the evaluation of PDR and RNV remain elusive. In total, 40 Chinese type-2 diabetes with DR and 21 non-diabetic subjects were recruited. Tear glycometabolic profiles and glycometabolite levels were comprehensively analyzed using both untargeted and targeted metabolomics approaches. Additionally, we employed multivariable logistic regression models, Pearson correlation analysis, receiver operating characteristic curve (ROC), retinal non-perfusion area detection and choroid sprouting assay to evaluate and validate the association betwe

SUBMITTER: Wen X 

PROVIDER: S-EPMC12270997 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature