Efficacy of Topical Antifungal Nail Solution Versus Topical Placebo Solution for the Treatment of Pedal Onychomycosis: A Randomized Controlled Trial.

ABSTRACT:

Introduction

Pedal onychomycosis is common, and its treatment entails debridement combined with topical and/or oral antifungal medication.

Methods

In this study, 69 participants were randomly allocated to either active (31 [44.93%]) or placebo (38 [55.07%]) topical solution. The primary outcome was mycological cure, and secondary outcomes included visible nail plate involvement and toenail-related quality of life.

Results

After a minimum duration of follow-up of 7 months and a maximum of 9 months, participants in the active solution group experienced statistically significantly greater mycological cure (1 [2.63%] placebo versus 17 [54.84%] active, p < 0.0001) and clinical cure (2 [5.56%] placebo versus 21 [70%] active, p < 0.0001), including 47.62% of which showed com

SUBMITTER: Malay DS 

PROVIDER: S-EPMC12271011 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature