High expression of DGKA indicates poor overall survival of nasopharyngeal carcinoma.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is a malignant tumor with strong tendency of metastasis and recurrence. Therefore, prognostic indicators for NPC are urgently needed. DGKA is overexpressed in many cancers. However, the role of DGKA in NPC remains unclear. The aim of this study is to investigate the expression patterns and prognostic value of DGKA in NPC.

Methods

The mRNA expression of DGKA was analyzed from the dataset of The Cancer Genome Atlas (TCGA). Immunohistochemistry was performed to detect the expression of DGKA in 124 paraffin-embedded samples. Survival analysis was conducted according to the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to identify the independent prognostic factors.

Results

We found the mRNA exp

SUBMITTER: Chen H 

PROVIDER: S-EPMC12271027 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature