Auger electron-emitting EGFR-targeted and non-targeted [¹⁹⁷Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM).

ABSTRACT:

Background

We describe here radiation nanomedicines for glioblastoma multiforme (GBM) composed of gold nanoparticles (AuNPs) that integrate the Auger electron-emitter, ¹⁹⁷Hg. [¹⁹⁷Hg]Hg-AuNPs were conjugated to anti-epidermal growth factor receptor (EGFR) panitumumab or were non-targeted. Our aim was to compare the cytotoxicity and DNA-damaging properties in vitro of panitumumab-[¹⁹⁷Hg]Hg-AuNPs and non-targeted [¹⁹⁷Hg]Hg-AuNPs on U251-Luc human GBM cells and estimate their cellular dosimetry. We further aimed to compare the biodistribution in vivo of panitumumab-[¹⁹⁷Hg]Hg-AuNPs and [¹⁹⁷Hg]Hg-AuNPs after convection-enhanced delivery (CED) in NRG mice with U251-Luc tumours in the brain and estimate the absorbed doses in

SUBMITTER: Brown MK 

PROVIDER: S-EPMC12271031 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature