Modeling of a population-based input function (PBIF) using the Feng model in dynamic ⁶⁸Ga-DOTATOC whole body PET/CT scans: feasibility of shortened imaging protocols on PET/CT Vision 600 system ^®.

ABSTRACT:

Background

This study focuses on modeling a population-based input function (PBIF) in dynamic ⁶⁸Ga-DOTATOC PET/CT exams, with the aim of developing clinically adoptable protocols. The PBIF is derived from an image-derived input function (IDIF), ensuring a non-invasive and standardized approach to tracer kinetic modeling.

Methods

Patients with well-differentiated neuroendocrine tumors were included from the GAPETNET clinical trial (n = 37), divided into a PBIF modeling group (n = 20) and an independent validation group (n = 17). Dynamic whole-body (dWB) PET/CT imaging was performed using a Vision 600 PET/CT system. A population-based input function (PBIF) was modeled using the Feng approach and scaled to individual patient-specific IDIFs over two different time windows (sPBIF

SUBMITTER: Godefroy T 

PROVIDER: S-EPMC12271040 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature