UNC93B1: a novel immune-related prognostic biomarker in breast cancer.

ABSTRACT: Breast cancer (BRCA) is a prevalent and deadly disease among women. This study investigated the role of UNC93B1, a gene associated with immune function, in BRCA prognosis and immune infiltration. Differentially expressed mRNA (DEmRNA) data related to the prognosis and immunity of BRCA patients were obtained from TCGA, GTE, GEO, and ImmPort databases. The Kruskal-Wallis test was used to identify clinicopathological parameters associated with UNC93B1 expression. Univariate and multivariate COX regression analyses were performed to assess the impact of UNC93B1 expression and clinicopathological parameters on patient survival. We analyzed the target genes' relevant functions and signaling pathways through enrichment analysis. Furthermore, the relationship between UNC93B1 expression and tumor i

SUBMITTER: Tian L 

PROVIDER: S-EPMC12271042 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature