Extruded nanovesicles derived from umbilical cord mesenchymal stem cells exhibit No tumorigenic potential.

ABSTRACT: Mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (MSC EVs) have gained significant attention in biomedical and therapeutic applications. Nevertheless, their translation in clinical practice remains limited due to the lack of scalable manufacturing techniques and the prevailing safety concerns. Cell-derived extruded nanovesicles (eNVs) with high production efficiency are regarded as promising substitutes of EVs. However, like MSC EVs, their potential for tumorigenicity has yet to be exhaustively investigated. In this work, we investigated the tumorigenicity of umbilical cord mesenchymal stem cell-derived eNVs (UMSC eNVs). A549 cancer cell-derived eNVs (A549 eNVs) with potential tumorigenicity were also prepared for comparative analysis. Our characterization findings reve

SUBMITTER: Wang F 

PROVIDER: S-EPMC12271084 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature