Effect of chorioamnionitis on necrotizing enterocolitis in preterm infants: a multicenter cohort study.

ABSTRACT:

Background

To explore the association between maternal chorioamnionitis (CAM) exposure and necrotising enterocolitis (NEC) in very preterm infants (VPI) or very low birth weight (VLBWI).

Methods

The aim of this multicentre cohort study was to investigate the impact of maternal CAM and its different staging on VPI or VLBWI NEC in six medical centres in Shenzhen between 2022 and 2023. The primary outcome was NEC (Bell staging ≥ II) and secondary outcomes included NEC or in-hospital mortality. Logistic regression adjusted for confounders identified through directed acyclic graphs (DAG) and literature review. The interaction effect of premature rupture of membranes was assessed using stratification and likelihood ratio tests.

Results

In the cohort study, the prevalence of

SUBMITTER: Guo X 

PROVIDER: S-EPMC12271088 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature