Inflammatory and metabolic markers mediate the association between urinary metals and non-alcoholic fatty liver disease in U.S. adults: a cross-sectional study.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a global public health problem. Inflammation, oxidative stress, and insulin resistance are involved in the development and progression of NAFLD. Although the etiology of NAFLD remains unclear, environmental factors are increasingly recognized as non-negligible risk factors. This study was to evaluate the urine metal associated with the risk of NAFLD and inflammation and metabolic markers mediating role.

Methods

According to the national health and nutrition examination survey (NHANES), to detect the metal concentration in the urine of 3,948 U.S. adults, including barium (Ba), cadmium (Cd), cobalt (Co), and cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), and uranium (Tu). Multivariate logistic regr

SUBMITTER: Li SY 

PROVIDER: S-EPMC12271117 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature