Dysbiosis and genomic plasticity in the oily scalp microbiome: a multi-omics analysis of dandruff pathogenesis.

ABSTRACT:

Introduction

Dandruff, affecting ~50% of the global population, is a prevalent scalp condition linked to microbial dysbiosis and inflammation, significantly impacting quality of life.

Methods

This study employed an integrative omics approach, utilizing 16S rRNA and ITS1 amplicon sequencing alongside shotgun metagenomics, to analyze the scalp microbiome of 65 individuals with varying scalp conditions (healthy oily, healthy non-oily, and dandruff oily).

Results

Distinct microbial profiles were identified, with an increased abundance of pathogenic genera such as Staphylococcus in the dandruff oily (DO) group, contrasted with the presence of Cutibacterium in healthy cohorts.

Discussion

Functional profiling revealed elevated DNA repair mechanisms in the DO group, in

SUBMITTER: Yu H 

PROVIDER: S-EPMC12271121 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature