Circulating adiponectin levels in systemic sclerosis: A meta-analysis and bidirectional Mendelian randomization study.

ABSTRACT:

Background

Previous data on the relationship between adiponectin and systemic sclerosis are inconsistent and do not establish a causal link. We aimed to perform an updated meta-analysis to estimate the association between circulating adiponectin and systemic sclerosis. Using a two-sample, bidirectional, Mendelian randomization approach, we also tested for a causal relationship between genetically predicted adiponectin levels and systemic sclerosis risk.

Methods

We conducted a systematic literature search of PubMed, Embase, and Web of Science (up to September 2024) to identify studies for meta-analysis. Pooled standardized mean differences were calculated. For bidirectional Mendelian randomization, genetic instruments for circulating adiponectin levels and liability to system

SUBMITTER: Fatima T 

PROVIDER: S-EPMC12271137 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature