Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum.

ABSTRACT:

Introduction

The cerebellar cortex is now recognized as a functionally heterogeneous brain region involved not only in traditional motor functioning but also in higher-level emotional and cognitive processing. Similarly, cerebellar astrocytes also display a high degree of morphological and functional diversity based on their location. Yet, the morphological features and distribution of cerebellar astrocytes have yet to be quantified in the human brain.

Methods

To address this, we performed a comprehensive postmortem examination of cerebellar astrocytes in the healthy human brain using microscopy-based techniques. Purkinje cells (PCs) were also quantified due to their close relationship with Bergmann glia (BG). Using canonical astrocyte markers glial fibrillary acidic protein

SUBMITTER: Hercher C 

PROVIDER: S-EPMC12271190 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature