Case Report: "<i>DEK::AFF2</i> fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies".

ABSTRACT:

Background

DEK::AFF2 fusion-associated carcinomas of the sinonasal tract are exceedingly rare, with fewer than 100 cases reported worldwide, but probably underrecognized. Recently classified by the WHO as a distinct provisional subtype of non-keratinizing squamous cell carcinoma, these tumors pose significant diagnostic and therapeutic challenges. Their histological resemblance to inverted papillomas and their bland histology in most cases often leads to misdiagnosis, while their aggressive behavior underscores the need for a tailored treatment approach.

Case presentation

We report two cases of DEK::AFF2 fusion-associated carcinomas managed at Saarland University Medical Center. The first case involved a 46-year-old woman who initially presented with recurrent

SUBMITTER: Knebel M 

PROVIDER: S-EPMC12271193 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature