Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in <i>NDUFAB1</i>+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasion.

ABSTRACT:

Background

Globally, gastric cancer (GC) stands as the fifth most prevalent form of malignant neoplasm and represents a significant contributor to mortality associated with oncological conditions. Despite advancements in therapeutic strategies for GC, the outcomes for patients with advanced stages of the disease continue to be unfavorable, largely due to tumor heterogeneity and the challenges posed by resistance to therapeutic agents. Metabolic reprogramming is pivotal in driving the advancement of GC, contributing to the development of resistance to pharmacological treatments and facilitating the cancer's ability to evade immune surveillance. Developing multi-target comprehensive treatment strategies by integrating tumor microenvironment (TME) modulation holds promise for signific

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12271198 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature