Association of <i>Helicobacter pylori</i> infection with the risk of neurodegenerative disorders: a systematic review and meta-analysis.

ABSTRACT:

Objective

The pathogenesis of neurodegenerative diseases is complex, involving multiple factors, including genetic, environmental, and lifestyle elements. Recent studies have suggested that infectious agents may act as important triggers for neurodegenerative diseases. This study aimed to evaluate the association between Helicobacter pylori (H. pylori) infection and the risk of neurodegenerative disorders through a systematic review and meta-analysis of existing literature.

Methods

A systematic search was conducted across the PubMed, Embase, and Cochrane Library databases for studies published up to December 2024. The combined effect sizes were expressed as odds ratios (OR) with 95% confidence intervals (CI) and were calculated using a random-effects model. Fur

SUBMITTER: Du J 

PROVIDER: S-EPMC12271219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature