Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis.

ABSTRACT:

Objective

Noise-induced hearing loss (NIHL), resulting from occupational noise exposure, is a significant health concern with considerable economic and social implications. It is the most commonly reported occupational disease in developing countries. Noise causes cochlear cell damage by inducing mitochondrial oxidative stress elevating reactive oxygen species (ROS), ultimately leading to cell apoptosis. This study explores the impact of noise-induced oxidative stress on mitochondrial DNA methylation and aims to identify potential molecular biomarkers for NIHL.

Methods

This study included 40 cases of NIHL and 40 controls. Mitochondrial genome-wide methylation sequencing was performed using a targeted region approach with bisulfite multiplex PCR capture technology and high-de

SUBMITTER: Wang D 

PROVIDER: S-EPMC12271232 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature