Identification of a fibroblast-derived gene signature reveals prognostic and therapeutic insights in pancreatic cancer.

ABSTRACT: Fibroblasts play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop a prognostic model based on fibroblast-specific gene signatures and identify key genes that may serve as therapeutic targets. Single-cell RNA sequencing data from PDAC and adjacent normal tissues were analyzed using high-dimensional weighted gene co-expression network analysis, and a prognostic signature was constructed using LASSO Cox regression and validated across multiple cohorts. Our findings revealed distinct fibroblast clusters enriched in PDAC and led to the development of a fibroblast-related prognostic signature comprising 14 key genes. The fibroblast-related risk score effectively stratified patients into high-risk and low-risk groups, revealing differences

SUBMITTER: Wang W 

PROVIDER: S-EPMC12271249 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature