Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), but up to 40% of patients have refractory or relapsing disease and show unsatisfactory responses to salvage treatment. Heat shock factor 1 (HSF1) regulates the transcription of a group of oncogenes, promoting chemoresistance and representing a promising therapeutic target. However, the role and mechanism of HSF1 in DLBCL remain unknown. In this study, we discovered that the overexpression of HSF1 was correlated with unfavorable treatment response and poor prognosis in patients with DLBCL. Inhibition of HSF1 via shRNA or DTHIB, a pharmacological inhibitor of HSF1, inhibited cell proliferation and increased chemosensitivity to vincristine and doxorubi

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12271312 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature