Atroposelective construction of axially chiral alkenylindole-fused nine-membered rings via catalytic asymmetric formal (4 + 5) cycloaddition.

ABSTRACT: Catalytic atroposelective construction of axially chiral aryl-fused medium-sized rings, particularly nine-membered rings, is of great importance but with enormous challenges. To overcome these challenges, in this work, the catalytic atroposelective construction of axially chiral arylalkene-fused nine-membered rings has been established, which makes use of organocatalytic asymmetric formal (4 + 5) cycloaddition of 3-alkynyl-2-indolylmethanols with 2-indolylethanols. By this strategy, various axially chiral alkenylindole-fused nine-membered rings were constructed in high enantioselectivities with moderate to good yields (up to 74% yield, 98% ee). Theoretical calculations provide an in-depth understanding on the reaction pathway and activation mode of the organocatalytic asymmetric formal (4 

SUBMITTER: Liu SJ 

PROVIDER: S-EPMC12271338 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature