Purification and characterization of an antimicrobial compound against drug-resistant MRSA and VRE produced by Streptomyces levis strain HFM-2.

ABSTRACT: Due to high resistance to medicines, multidrug-resistant (MDR) bacterial pathogens, particularly MRSA (methicillin-resistant Staphylococcus aureus) and VRE (vancomycin-resistant enterococci), are a significant public health concern for treating nosocomial infections. Researchers are developing novel compounds responding to the global rise in MDR infections. This study aimed to extract, purify, and characterize bioactive metabolites from Streptomyces levis strain HFM-2, a human gut isolate, exhibiting strong antimicrobial activity against several MDR pathogenic bacteria and fungal phytopathogens. Ethyl acetate extract of S. levis strain HFM-2 was purified using silica-gel column chromatography and reverse-phase high-performance liquid chromatography. Structure elucidation of the purified an

SUBMITTER: Verma J 

PROVIDER: S-EPMC12271353 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature