Comparison of conventional and radiomics-based analysis of myocardial infarction using multimodal non-linear optical microscopy.

ABSTRACT: Myocardial infarction, a leading cause of mortality worldwide, leaves survivors at significant risk of recurrence caused by scar-related re-entrant ventricular tachyarrhythmias. Effective treatment with ablation therapy requires a precise guidance system. Non-linear optical microscopy techniques, such as second harmonic generation (SHG) and two-photon excited fluorescence (TPEF), are promising candidates for a high-resolution alternative to conventional electrical mapping for assessing infarcted cardiac tissue. Here, we apply SHG and TPEF with a resolution advantage over commonly used electrical mapping techniques to assess ex-vivo sheep heart infarction. Analyzing conventional and radiomic features allows for quantitative characterization of scar tissue. Our machine learning classifier ac

SUBMITTER: Giardina G 

PROVIDER: S-EPMC12271366 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature