Light-activated multimodal nanoplatform for enhanced synergistic therapy of breast cancer.

ABSTRACT: Breast cancer poses a significant health threat to women, as traditional chemotherapy often fails due to multidrug resistance and tumor adaptability. Moreover, the anti-apoptotic nature of these tumors limits the effectiveness of conventional treatments. Current therapeutic approaches, including photodynamic therapy (PDT), face limitations in clinical application due to poor water solubility of photosensitizers and challenges in targeted delivery. This study aims to develop a multifunctional nanosystem that integrates PDT with gene therapy to enhance breast cancer treatment efficacy. Firstly, Fe₃O₄ hollow nanospheres were prepared to carry Ce6 drug to kill breast cancer cells via chemodynamic therapy and PDT, respectively. To overcome the drawback of poor water solubi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12271506 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature