Chromatin interaction maps of human arterioles reveal mechanisms for the genetic regulation of blood pressure.

ABSTRACT: Arterioles are small blood vessels located just upstream of capillaries in nearly all tissues. Despite the broad and essential role of arterioles in physiology and disease, current knowledge of the functional genomics of arterioles is largely absent. Here, we report extensive maps of chromatin interactions, single-cell expression, and other molecular features in human arterioles and uncover mechanisms linking human genetic variants to gene expression in vascular cells and the development of hypertension. Compared to large arteries, arterioles exhibited a higher proportion of pericytes which were enriched for blood pressure (BP)-associated genes. BP-associated single nucleotide polymorphisms (SNPs) were enriched in chromatin interaction regions in arterioles. We linked BP-associated noncodi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12271514 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature