Generating brain-wide connectome using synthetic axonal morphologies.

ABSTRACT: Recent experimental advancements, including electron microscopy reconstructions, have produced detailed connectivity data for local brain regions. On the other hand, for inter-regional connectivity, large-scale imaging techniques such as MRI are best suited to provide insights. However, understanding the relationship between local and long-range connectivity is essential for studying both healthy and pathological conditions of the brain. Leveraging a dataset of whole-brain axonal reconstructions, we present a technique to predict whole-brain connectivity at single cell level for pyramidal cells in the cortex by generating detailed whole-brain axonal morphologies from sparse experimental data. The computationally generated axons accurately reproduce the local and global morphological proper

SUBMITTER: Petkantchin R 

PROVIDER: S-EPMC12271523 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature