Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD.

ABSTRACT:

Background

The unique stress response state of T cells (Tstr) is found in various cancers and correlates with altered Lung Adenocarcinoma (LUAD) tumor microenvironment and immunotherapy outcomes. However, fewer studies have been described on the relationship between Tstr and LUAD, and its mechanism of action in the pathogenesis of LUAD needs to be further investigated.

Methods

The categorization and validation of cluster types for Tstr signature genes were systematically carried out using transcriptomic data sourced from the TCGA and GEO databases. The focus was on elucidating distinct pharmacological characteristics, tumor microenvironmental traits, and immunotherapeutic benefits across various subtypes. Moreover, a predictive model was developed through Least Absolute Shri

SUBMITTER: Min S 

PROVIDER: S-EPMC12271563 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature