In-silico docking analysis of bioactive compounds sourced from Punica granatum peel extract: Approaching a precision solution for ovarian cancer.

ABSTRACT:

Background

The MAPK signalling pathways, particularly those involving EGFR and VEGFR, play a pivotal role in the initiation and progression of ovarian cancer. Inadequate regulation of these pathways may lead to uncontrolled cell proliferation, angiogenesis, and metastasis. Targeting mitogen-activated protein kinases (MAPKs), including the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR), has demonstrated significant potential in restraining cancer cell proliferation and angiogenesis, representing a promising avenue among various therapeutic strategies.

Objectives

This manuscript aims to investigate the possibility of Mashi a pomegranate peel extract for ovarian cancer treatment, specifically targeting MAPKs (EGFR and VEGFR). Pom

SUBMITTER: Hatolkar S 

PROVIDER: S-EPMC12271577 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature