Intratumor <i>Rhodococcus</i> sp. <i>B513</i> drives DEN-induced hepatocellular carcinoma progression by modulating gut microbiota and angiogenesis.

ABSTRACT: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality worldwide with challenging clinical treatment. Accumulating evidence demonstrates that gut dysbiosis promotes HCC progression, and intratumoral bacteria play an essential role in carcinogenesis by modulating the tumor immune microenvironment. However, the microbiome within liver tumor tissues remains poorly characterized. In this study, we investigated the intratumoral microbiota of HCC and identified a specific bacterial taxon, Rhodococcus sp. B513, that was enriched in tumor tissues. We found that Rhodococcus sp. B513 promoted HCC development partially by inducing vascular endothelial growth factor (VEGF) expression and promoting angiogenesis. Moreover, Rhodococcus sp

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12271595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature