Comparative acute toxicity of intravenous paclitaxel and sirolimus in rats.

ABSTRACT:

Aim

In view of the exploration of sirolimus (rapamycin) as balloon coating for peripheral intravasal treatment and the reports on unfavorable tolerance of daily low-dose sirolimus, the aim of the study was to investigate potential toxicological effects of a single intravascular dose of sirolimus in comparison to paclitaxel and vehicle in the rat.

Methods

Rats were treated intravenously with a single dose of 20 mg/kg sirolimus or paclitaxel dissolved in identical vehicle and sacrificed 5- or 14-days post treatment. Vehicle (Cremophor EL/Ethanol diluted with saline) treated rats served as a control. Potential effects on survival, hematology, organ weights, organ histology were analyzed.

Results

Single dose i.v. injection of sirolimus, paclitaxel and vehicle induced temp

SUBMITTER: Xie J 

PROVIDER: S-EPMC12271596 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature