Cell-type specific binocular interactions in mouse visual thalamus.

ABSTRACT: To determine whether intrinsic circuits of the dorsal lateral geniculate nucleus (dLGN) mediate excitatory and/or inhibitory binocular interactions, in vitro dual color optogenetics was used to examine convergence of eye-specific retinal inputs to thalamocortical (relay) cells and GABAergic interneurons. Both relay cells and interneurons were found to receive direct binocular retinogeniculate input, but the incidence was higher for interneurons. Moreover, the distribution of binocular relay cells was limited to regions in and around the ipsilateral patch of retinogeniculate terminals, while binocular interneurons were distributed throughout the dLGN. Accordingly, retinogeniculate-evoked inhibitory interactions were common. Retinal inputs arising from either eye inhibited the majorit

SUBMITTER: Masterson SP 

PROVIDER: S-EPMC12271621 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature