GSK-3β and mTOR Phosphorylation Mediate the Reversible Regulation of Hypomagnetic Field on Adult Neural Stem Cell Proliferation.

ABSTRACT: Exposure to hypomagnetic field (HMF) of < 5 μT has been demonstrated to impair cognitive behaviors in mammals by disrupting neurogenesis. This process could potentially be modulated by the protein phosphorylation of adult neural stem cells (aNSCs) that are highly sensitive to environmental changes. However, the effects of HMF on aNSCs protein phosphorylation remain unclear. Here, we found that HMF reversibly regulates the effects on aNSC proliferation by modulating protein phosphorylation in aNSCs. Specifically, HMF inhibits aNSCs proliferation by reducing glycogen synthase kinase 3β (GSK-3β) phosphorylation, and when aNSCs are returned from HMF to the geomagnetic field (rGMF), rGMF activates mammalian target of rapamycin (mTOR) phosphorylation to restore their proliferation. These finding

SUBMITTER: Ren J 

PROVIDER: S-EPMC12271677 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature