Clinical Significance of Low-Density Granulocytes in Acute Pancreatitis.

ABSTRACT: Background: Low-density granulocytes (LDGs), a unique subset of neutrophils, have been shown in previous studies to exhibit distinct biological functions in immune-inflammatory diseases. However, their role in acute pancreatitis (AP) remains unclear. Objective: To investigate the association between peripheral blood LDGs levels and clinical severity in patients with AP. Methods: This cross-sectional study analyzed peripheral LDGs levels in 41 mild AP (MAP) patients, 40 moderate-to-severe AP (SAP) patients, and 41 healthy controls (HC). LDGs were measured within 24 h of admission. Statistical analysis, including Kruskal-Wallis tests and logistic regression, assessed LDGs' association with clinical characteristics and AP severity. Results: LDGs levels were signifi

SUBMITTER: Wang J 

PROVIDER: S-EPMC12271696 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature