Lactate-to-albumin ratio index correlates with the occurrence and prognosis of acute kidney injury complicated by cardiac surgery.

ABSTRACT:

Background

The lactate-to-albumin ratio (LAR) is a novel biomarker associated with poor prognosis in critical illnesses. However, its relationship with cardiac surgery associated acute kidney injury (AKI) and prognosis remains unclear. This study aimed to investigate this relationship using data from the MIMIC database.

Methods

A retrospective cohort study was conducted on 11,624 adult cardiac surgery patients admitted to the ICU. Logistic regression, restricted cubic spline (RCS) analysis, and subgroup analysis were used to assess the predictive value of LAR for AKI occurrence and adverse outcomes.

Results

Of the 11,624 patients, 5,965 developed AKI. While LAR concentrations were higher in AKI patients, this association did not persist after multivariate adjustment f

SUBMITTER: Wang C 

PROVIDER: S-EPMC12271795 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature