Highly tough and conformal silk-based adhesive patches for sutureless repair of gastrointestinal and peripheral nerve defects.

ABSTRACT: The use of tissue adhesive patches provides a promising therapeutic approach for sutureless repair of soft tissue injuries. However, existing tissue adhesive patches are confronted with serious challenges for clinical applications in the soft tissue environments with biological fluids and dynamic movements. Either their mechanical toughness does not match that of soft tissues, or they fail to establish effective interfacial bonding with tissues in wet conditions. The imbalance between the mechanical cohesion and interfacial adhesion of existing tissue adhesive patches severely restricts their conformal integration with wet surfaces of soft tissues in dynamic biological environments, leading to adhesion failure in clinical applications. Here, this study reports the design, fabrication, and

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12271796 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature