Gestational diabetes and parental type 2 diabetes as risk indicators for type 1 diabetes in offspring: a systematic review and meta-analysis.

ABSTRACT:

Background

Type 1 diabetes can be accelerated by insulin resistance, an increasingly prevalent condition. Some studies report an association between offspring type 1 diabetes development and insulin resistant parental diabetes, namely type 2 and gestational diabetes. We aimed to evaluate and synthesize this evidence, to delineate risk indicators for early detection and, potentially, for prevention.

Methods

We conducted a systematic review and meta-analyses for studies assessing associations between gestational diabetes, maternal type 2 diabetes, and/or paternal type 2 diabetes, with offspring type 1 diabetes. We searched Embase, PubMed/Medline, Cochrane and Scopus from inception to April 30, 2025, without language restrictions. We assessed study quality, extracted summary da

SUBMITTER: Albanese I 

PROVIDER: S-EPMC12271811 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature