Longitudinal Assessment and Cost-Benefit Analysis of Prophylactic Fenestration in Chondrodystrophic Dogs With Follow-Up Magnetic Resonance Imaging.

ABSTRACT:

Background

Prophylactic fenestration (PF) has been reported to protect against recurrent intervertebral disc extrusion (IVDE), but recurrence is not always confirmed. No published studies address the cost-benefit of PF.

Objectives

Observe the association between PF and intervertebral disc (IVD) survival and conduct cost-benefit analysis.

Animals

Eighty chondrodystrophic dogs with recurrent IVDE.

Methods

Longitudinal assessment with follow-up magnetic resonance imaging (MRI) was performed to retrospectively observe the survival of in situ IVDs. The association between PF and IVD survival was analyzed using a multivariable survival model, which included Pfirrmann grade as a covariate. Worst-case, base-case, and best-case cost-benefit simulations were conducted, c

SUBMITTER: Low D 

PROVIDER: S-EPMC12271825 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature