GLP-1 and GIP may play a role in long-term weight trajectories after gastric bypass.

ABSTRACT:

Introduction

Suboptimal clinical responses to metabolic and bariatric surgery include insufficient weight loss (WL), weight regain (WR), and/or comorbidity remission failure or relapse. Gut hormones' role in WR and Type 2 diabetes (T2D) relapse is not fully established. So, our aim was to evaluate the hormone profiles of patients with long-term optimal and suboptimal response after gastric bypass (RYGB).

Methods

This cross-sectional study included 43 individuals who underwent RYGB surgery over 10 years ago, divided into two groups: 23 participants with no T2D history but different WR trajectories (cohort 1), and 20 with prior T2D diagnosis and optimal WL (cohort 2), with post-RYGB T2D remission (n=10) or relapse (n=10).

Results

Fasting and postprandial glucose, insuli

SUBMITTER: Andrade S 

PROVIDER: S-EPMC12271881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature