The impact of magnitude and duration of plasma viremia during analytical treatment interruptions on CD4⁺ T cell recovery after ART resumption.

ABSTRACT:

Objective

Analytical treatment interruption (ATI) is crucial for assessing the efficacy of HIV-1 cure strategies. Recent cure studies have implemented more flexible ART restart criteria, permitting higher plasma viral loads (pVLs) for longer periods, which could potentially impair CD4⁺ T cell recovery even following ART resumption.

Design

We conducted a pooled analysis of six clinical HIV cure trials that included an ATI to evaluate the impact of magnitude and duration of plasma viremia during ATI on CD4⁺ T cell dynamics.

Methods

Wilcoxon signed-rank or rank-sum test was used to analyze differences in CD4⁺ T cell counts from 3 time points: 1) pre-ATI, 2) ART resumption, and 3) ART-induced viral re-suppression, with analyses stratified

SUBMITTER: Klastrup V 

PROVIDER: S-EPMC12271902 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature