Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways.

ABSTRACT:

Background

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe systemic complications and reduced quality of life. Current therapies often fail to comprehensively alleviate diabetic complications, highlighting the need for novel approaches. Animal studies and clinical trials have demonstrated the therapeutic potential of molecular hydrogen (H₂), particularly in controlling DM. However, no systematic studies have investigated the long-term treatment effects of hydrogen-rich water (HRW) on DM, and the underlying mechanisms remain largely unknown. This study aims to explore the therapeutic efficacy of HRW in mitigating DM-related complications and uncover its molecular mechanisms using a streptozotocin (STZ)-in

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12271932 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature