Leveraging hypoxia-related genes signature for predicting the prognosis of bladder cancer.

ABSTRACT:

Background

Hypoxia is common in solid tumors, facilitating tumor growth and treatment resistance, and is crucial for optimizing patient outcomes, but research on the mechanism of hypoxia in bladder cancer (BC) remains limited. This study aims to explore the functional role of hypoxia-related genes (HRGs) in BC.

Methods

The HRGs were obtained from GeneCards, and the hypoxia score in BC patients was evaluated by single-sample gene set enrichment analysis (ssGSEA). The prognostic risk model was constructed using differentially expressed prognostic HRGs, and assessed via time-dependent receiver operating characteristic (ROC) curves, Kaplan-Meier (KM) curve, and nomogram analysis. Differential features between high- and low-risk groups were analyzed, including clinical characteri

SUBMITTER: Dong Y 

PROVIDER: S-EPMC12271935 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature