SChLAP1 regulates the metastasis and apoptosis of prostate cancer partly via miR-101.

ABSTRACT:

Background

Prostate cancer (PC) remains one of the leading causes of cancer-related mortality, necessitating further research into novel prognostic biomarkers and therapeutic targets. Long noncoding RNA second chromosome locus-associated with prostate-1 (SChLAP1) plays a crucial role in the aggressiveness of PC; however, its precise mechanism remains unclear. This study aimed to investigate the role of SChLAP1 in PC metastasis and apoptosis, with a particular focus on its interaction with miR-101.

Methods

The expression levels of SChLAP1 were analyzed by quantitative polymerase chain reaction (qPCR) and fluorescence in situ hybridization (FISH) in 42 clinical specimens, including 21 PC tissues and their corresponding adjacent normal tissues, as well as in PC cell lines (PC-3

SUBMITTER: Huang X 

PROVIDER: S-EPMC12271948 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature