Targeted Gas Chromatography-Mass Spectrometry Analysis of 31 Phthalates and Replacements: Method Optimization and Application to Edible Oils and Silicone Wristbands.

ABSTRACT: Interest in phthalate detection of foods and other environmental media has grown rapidly in the past decade. However, current analytical and separation techniques are often limited in the breadth of chemistry targeted, most often targeting less than 15 compounds. Challenges to successful methods with this compound group include chromatographic resolution, quantitation across diverse concentration ranges, and sample preparation due to the chemical similarity of these compounds. This project describes the development of a selective ion monitoring gas chromatography mass spectrometry method for quantitation of 29 phthalates and two phthalate replacements along with considerations for quantitation, sample cleanup, and standard storage. Our range of phthalates includes less-studied ones like bi

SUBMITTER: Adams KT 

PROVIDER: S-EPMC12272031 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature