Tailoring Self-Assembled Peptide Hydrogels with Antimicrobial or Cell Adhesive Properties for Tissue Engineering.

ABSTRACT: Bacterial colonization on biomaterials is a major issue, leading to approximately 20% of implant failures due to infection and biofilm formation. To address this, peptide-based hydrogels incorporating tailored bioactive peptides have emerged as promising candidates for applications in tissue engineering and infection control. Here, we have designed peptide sequences that incorporate i) a self-assembling unit (SaU) and ii) bioactive motifs, including the well-known arginine-glycine-aspartate (RGD) sequence to promote cell adhesion or an antimicrobial peptide derived from lactoferrin (LF) to exhibit antibacterial properties. To aid in the gelation, these peptides were combined with hyaluronic acid (HA), rendering peptide-based hydrogels without the need for additional external assembly trigg

SUBMITTER: Lopez-Gomez P 

PROVIDER: S-EPMC12272040 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature