Transient Receptor Potential Ankyrin 1 (TRPA1) Mediates Hydrogen Sulfide-induced Ca²⁺ Entry and Nitric Oxide Production in Human Cerebrovascular Endothelium.

ABSTRACT:

Introduction

The gasotransmitter hydrogen sulfide (H₂S) modulates various brain functions, including neuron excitability, synaptic plasticity, and Ca²⁺ dynamics. Furthermore, H₂S may stimulate nitric oxide (NO) release from cerebrovascular endothelial cells, thereby regulating NO-dependent endothelial functions, such as angiogenesis, vasorelaxation, and cerebral blood flow (CBF). However, the signaling pathway by which H₂S induces NO release from cerebrovascular endothelial cells is still unclear.

Methods

Herein, we exploited single-cell imaging of intracellular Ca²⁺, H₂S, and NO levels to assess how H₂S induces Ca²⁺-dependent NO release from the human cerebrovascular endothelial cell lin

SUBMITTER: Soda T 

PROVIDER: S-EPMC12272095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature