Impact of Normal Lung Volume Choices on Radiation Pneumonitis Risk Prediction in Locally Non-small Cell Lung Cancer Radiation Therapy.

ABSTRACT:

Purpose

This study aims to evaluate the impact of varying definitions of normal lung volume on the prediction of radiation pneumonitis (RP) risk in patients with locally advanced non-small cell lung cancer undergoing radiation therapy.

Methods and materials

Dosimetric variables V20, V5, and mean lung dose (MLD) were extracted from the treatment plans of 442 patients enrolled in the NRG Oncology Radiation Therapy Oncology Group 0617 trial. Three different definitions of lung volume were evaluated: total lung excluding gross tumor target, total lung excluding clinical target volume, and total lung excluding planning target volume (TL-PTV). Patients were grouped as "no-RP2" (N = 377, grade ≤1 RP) and "RP2" (N = 65, grade ≥2 RP). Statistical analyses were performed

SUBMITTER: Gadsby A 

PROVIDER: S-EPMC12272110 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature