Definitive Radiation Therapy for Ewing Sarcoma: Outcomes Based on Tumor Volume, Dose, and Fractionation.

ABSTRACT:

Purpose

Dose escalation for definitive radiation therapy (DE-RT) in larger Ewing sarcomas (ESs) is associated with a lower risk of local recurrence. We report treatment and toxicity outcomes in ES tumors treated with DE-RT, including hypofractionated approaches and size stratification of analysis.

Methods and materials

A retrospective review of ES patients treated with DE-RT to doses ≥55.8 Gy was performed. Local failure (LF) with death as a competing risk was assessed. Maximally selected rank statistics were used to determine the optimal stratification of patients by survival using tumor size measurements.

Results

In total, 47 patients were analyzed. Twenty-eight patients (59.6%) received DE-RT, of which 6 received hypofractionation. For DE-RT, median equivalent dose

SUBMITTER: Weiskittel TM 

PROVIDER: S-EPMC12272112 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature