Joint effects of atrial fibrillation and prothrombotic genotypes on the risk of venous thromboembolism.

ABSTRACT:

Background

Atrial fibrillation (AF) is a risk factor for venous thromboembolism (VTE), but the role of common prothrombotic gene variants in this relationship is unknown.

Objectives

We investigated the joint effect of prothrombotic genotypes and AF on the risk of VTE in a population-based case-cohort.

Methods

Incident VTE cases (n = 1458) and a subcohort (n = 14,526) randomly sampled from the Tromsø (1994-2012) and Trøndelag Health (1995-2008) cohort studies were included. DNA was genotyped for rs8176719 (ABO), rs6025 (factor V Leiden [FVL]), rs1799963 (prothrombin), rs2066865 (fibrinogen gamma gene), and rs2036914 (F11). Hazard ratios (HRs) with 95% CIs for VTE were estimated by individual single-nucleotide polymorphisms and categories of a genetic risk

SUBMITTER: Hald EM 

PROVIDER: S-EPMC12272126 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature