Genetic Determinants of Leukocyte Count in Nonsyndromic Cleft Lip With or Without Cleft Palate Among Asians.

ABSTRACT:

Objectives

Previous studies have shown that maternal proinflammatory status could increase the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in offspring. This study aimed to assess the relationship between leukocyte counts and NSCL/P.

Methods

The NSCL/P genome-wide association study (GWAS) data with a total of 1069 cases and 1724 controls were included. Summary statistics for 6 leukocyte counts GWASs (white blood cell count (WBC), neutrophil count (NC), monocyte count (MONO), lymphocyte count (LYM), eosinophil count (EOS), and basophil count (BASO)) in large-scale East Asian populations were obtained from the IEU OpenGWAS database. Genetic association analyses include genetic correlations and genetic overlaps of traits. Multi-trait analysis was used t

SUBMITTER: Xing C 

PROVIDER: S-EPMC12272131 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature