Prevalence of colistin resistance in multidrug-resistant <i>Klebsiella pneumoniae</i> recovered from clinical samples in Africa: a systematic review and meta-analysis.

ABSTRACT:

Background

Colistin resistance in multidrug-resistant (MDR) Klebsiella pneumoniae is a growing concern in Africa, complicating treatment and public health management. Colistin is a last-resort antibiotic for Gram-negative infections, but its resistance in clinical settings presents significant challenges. This study aims to determine the pooled prevalence of colistin resistance in MDR K. pneumoniae isolates from clinical specimens in Africa.

Methods

Articles were sourced from PubMed, Scopus, ScienceDirect and Google Scholar. Studies included were those reporting colistin resistance in MDR K. pneumoniae from clinical specimens in Africa, using EUCAST and CLSI-standard drug susceptibility testing. Data were extracted into Excel and analysed using STATA 17

SUBMITTER: Gashaw Y 

PROVIDER: S-EPMC12272164 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature