Lifestyle can exert a significant impact on the development of metabolic comorbidities in early-stage colorectal cancer patients.

ABSTRACT:

Background

Metabolic dysregulation has been identified as contributing to colorectal cancer (CRC) development. However, there is a lack of data regarding the association between lifestyle factors and metabolic diseases in CRC patients.

Methods

We conducted a multi-center cross-sectional study including 437 early-stage CRC patients and 437 control participants between April 2023 and March 2024. The dietary inflammatory index (DII) was calculated based on dietary data, which was collected using a food frequency questionnaire. A healthy lifestyle was defined as adherence to an anti-inflammatory diet (DII score < 0) combined with active physical activity.

Results

Among early-stage CRC patients, overweight and obesity were associated with an anti-inflammatory diet (OR = 0.

SUBMITTER: Xin Y 

PROVIDER: S-EPMC12272228 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature