Following the Mixtures of Organic Micropollutants with <i>In Vitro</i> Bioassays in a Large Lowland River from Source to Sea.

ABSTRACT: Human-impacted rivers often contain a complex mixture of organic micropollutants, including pesticides, pharmaceuticals and industrial compounds, along with their transformation products. Combining chemical target analysis for exposure with in vitro bioassays for effect assessment offers a holistic view of water quality. This study targeted the River Elbe in Central Europe, known for its anthropogenic pollution exposure, to obtain an inventory of micropollutant contamination during base flow and to identify hotspots of contamination. We identified tributaries as sources of chemicals activating the aryl hydrocarbon receptor quantified with the AhR-CALUX assay, including historically contaminated tributaries and a newly identified Czech tributary. Increased neurotoxicity, detected by

SUBMITTER: Hommel E 

PROVIDER: S-EPMC12272280 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature